Metribolone is the most potent oral steroid ever made. This drug is a close relative of trenbolone, which differs only in 17-alpha-alkylation. This modification makes it significantly stronger than trenbolone. 120-300 times more potent than methyltestosterone. This is the most potent steroid available on the market, doses of 0.5-1 mg are sufficient for a strong anabolic effect. Its activity is accompanied by high toxicity, which limits its use under laboratory conditions.

General information

Metribolon was first described in 1965. It is one of the most powerful anabolic steroids ever sold in pharmacies. This medicine has only been used in laboratory studies. Studies of breast cancer treatment were conducted in the 1960s and 1970s that slowed down and in some cases reversed the process of tumor growth. The studies did not last long due to the detected toxicity.

In the mid-1970s, metribolone was tested on animals to bind to androgen receptors. It was very suitable for this purpose. Its activity and resistance to blood-binding proteins made it easier for it to become a reference substance. Due to its metabolic resistance, metabolites of metribolone did not affect the results of most experiments.

Structural properties

Metribolone is a modified nandrolone. The main differences are:

• Addition of a methyl group in the 17alpha position to protect the medicine when taken orally.
• Introduction of a double bond between carbon atoms 9 and 10, which reduces the bond and slows down the metabolism. This results in a very strong steroid with a long half-life and low ability to bind to blood proteins. In fact, metribolone differs from trenbolone in the c17-alpha position by the addition of only one methyl group. This change changes the activity of the drug and can not be called an oral analogue of trenbolone.

Estrogen side effects

Metribolone is not flavored and has no estrogenic activity. Dimethyltrienolone shows affinity for progesterone receptors. This can cause progesterone side effects such as stopping testosterone production and increasing body fat. Progestins also enhance the stimulating effect of estrogen on breast tissue growth. There is a synergy that gynecomastia alone can be caused by progestogens without increasing estrogen levels. Use of an antiestrogen can relieve gynecomastia caused by progestin-ASA.

Androgenic side effects

Metribolone is considered anabolic, but androgenic side effects are very likely. It can increase oily skin, acne, hair growth on body and face. Anabolic steroids can aggravate hair loss in men. In addition, women should be aware of the potential virilizing effects of AAS. This can include deepening of the voice, irregular menstruation, changes in the structure of the skin, growth of facial hair and enlargement of the clitoris. Metribolone does not react with 5α-reductase and its androgenicity cannot be altered when co-administered with finasteride or dutasteride.

Hepatotoxicity

Metribolone is a c17 alpha-alkylated drug. This change protects the drug from being deactivated by the liver and allows a larger proportion of the drug to enter the bloodstream after oral administration. Alkylated AAS may be hepatotoxic. Prolonged use or high doses can cause liver damage. In rare cases, life-threatening dysfunction may develop.

It is advisable to visit a doctor regularly during the course to check your liver function. Intake of alkylated ASA is usually limited to 6-8 weeks to avoid increased liver load. Metribolone is a very potent oral steroid and is very resistant to liver metabolism. Because of this, it is very toxic to the liver and has therefore never been sold in pharmacies.

It was published in Germany in 1966 at the University of Bonn. In fact, the researchers concluded that it is the most toxic drug for the liver: “Metribolone … is an orally active drug that exercises less than 1 milligram per day and has been tested for its effects on liver function.” Measurements were performed on several parameters: sulfobromolein retention, total bilirubin, transaminase activity, alkaline phosphatase, cholinesterase in the blood, proaccelerin activity in the blood plasma.

Based on the results of the effect on intrahepatic cholestasis, metribolone is the most hepatotoxic drug. It may be advisable to use liver cleansing supplements such as Liver Stable, Life-52 and Essentiale Forte during the course.

The cardiovascular system

AAS can adversely affect blood cholesterol levels. This may be a reduction in “good” HDL levels, a change in balance against the risk of atherosclerosis. The relative effect of ASA on lipids depends on the dose, route of administration, type of steroid and degree of resistance to liver metabolism. Metribolone has a stronger negative effect on the treatment of liver cholesterol due to its non-aromatic structure and route of administration.

ASA can adversely affect blood pressure and triglycerides, reduce vascular endothelial relaxation, cause ventricular dilation, and potentially increase the risk of cardiovascular disease and myocardial infarction. To reduce the load on the cardiovascular system, it is recommended to minimize the intake of saturated fats, cholesterol and simple carbohydrates during AAS. The use of dietary supplements such as fish oil, lipid stabilizers or similar products is recommended.

Suppression of testosterone

Each AAS suppresses the body’s own production of testosterone in the doses needed to build muscle. Without the intervention of testosterone boosters, testosterone returns to normal levels within 1 to 4 months after the cycle. Note that long-term hypogonadotrophic hypogonadism may progress to secondary hypogonadism and require medical attention.

Reception

Studies have shown that taking ASA orally with food reduces the bioavailability of the drug. This is because AAS is soluble in fat, which can cause some of the drug to dissolve in fat in food, reducing the absorption of AAS from the gastrointestinal tract. For maximum effect, this medicine should be taken on an empty stomach.

Metribolone is not approved for human use. This drug is not recommended for fitness purposes due to its high liver toxicity. Those who really want to use this drug should take its toxicity seriously. Regular blood tests are needed to ensure that the drug does not harm the liver. The drug is used for up to 4 weeks. 0.5 mg drug is sufficient to achieve a significant anabolic effect. The doses can vary from 0.5 mg to 2 mg daily.